The store opened as Kelly's Rexall Drugs and was 1,100 sq. ft. in size when it began operations on Bridge St. E. in September 1957. It has grown into a property of 12,000 sq. ft. and evolved as Kelly's Guardian Pharmacy & Home Health Centre. Mr. Paul Kelly has retained his role as president  and owner through the years. Son, Alan Kelly, has been the general manager since 1993.

Customer service and convenience to meet the communities' needs have been important to the store's success. Paul Kelly was a visionary when he opened the store outside of city limits so customers could shop on Sundays. The store was open on Wednesday afternoons when the rest of the drugstores in the city were closed. Kelly's is open 364 days a year, closed only on Christmas Day. Everyday is "Seniors Day" and "Free Delivery" is available to everyone within the city limits.

Kelly's Drug Store & Kelly's Home Health Centre are now conveniently together under one roof in Belleville with a second Home Health Centre in Trenton. Kelly's has been proudly part of the community for almost half a century.